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Buy Ganfort Online

We sell Generic Version of Original Ganfort, under brand name Careprost Plus made by Indian company.

Active substance:	Bimatoprost + Timolol
U.S. Brand:	Ganfort
Indian Brand:	Careprost Plus
Mfd by:
Strength:	0.03% + 0.5% w/v
Form release:	3ml bottle
Shipping time:	7 – 21 days
Best price:	12.00 USD
Order:	through request form

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DescriptionHow to take?Common Side EffectsLatest New'sPhoto's

Bimatoprost in combination with Timolol is used for treating ocular hypertension (by draining fluid from the eye) or increased pressure in the eye and open-angle glaucoma. It comes in the form of eye drops. Bimatoprost & Timolol released under US brand name: Ganfort, we sell 100% analog/generic brand CAREPROST PLUS is included in a class of medications called prostaglandin analogs, Generic Ganfrort – Careprost Plus made by trusted indian company Sun Pharma.

The drug should be used in the morning. If you miss one dose, continue with the next one.. The eye solution may vary from clear, colorless to slightly yellow in color. The medicine is available in 5 ml white opaque polyethylene bottle. Each bottle contains 3 ml of solution. The bottle should be kept tightly closed. It should be used within 30 days of opening the bottle.

Combination Bimatoprost & Timolol, It is generally advised to be used in the affected eye once daily. Both these drugs work differently to control the increased pressure level in the eye. While using these eye drops, be careful not to touch the tip of the dropper, as it may contaminate the tip as well as the solution. Sometimes, brand or generic Ganfort eye drops may temporarily blur your vision, therefore you are advised not to drive a vehicle or operate machinery for some time after using this drug.

Bimatoprost and timilol maleate may cause your eye color to change, which is completely normal. While you are taking this medication, you should go for regular checkup. This drug may also increase your sensitivity. You should consult your doctor if you have a history of allergies. It is also advised that brand or generic Ganfort eye drops be used cautiously if you have decreased liver or kidney function. You should talk with your doctor if you suffer from closed eye glaucoma.

Bimatoprost sustained-release implant shows positive phase 3 data

A bimatoprost sustained-release implant reduced IOP by approximately 30% over 12 weeks in a phase 3 clinical study, according to an Allergan press release.

The multicenter, randomized, masked, parallel-group study, which included 594 subjects with open-angle glaucoma or ocular hypertension, compared the efficacy and safety of two dose strengths of Bimatoprost SR and timolol eye drops used twice daily for up to 20 months. The study showed the majority of patients treated with Bimatoprost SR were potentially able to be treatment-free for 1 year after the last implant was inserted, the release said.

“Considering that as many as 80% of glaucoma patients fail to administer their drops on a regular basis, Bimatoprost SR has the potential to transform the management of glaucoma in millions of patients,” Bill Meury, chief commercial officer at Allergan, said in the release.

The implant was well tolerated in the majority of patients. Additional safety data from this study, as well as results from a second phase 3 study, are expected to be reported in the first half of 2019, and the company expects to file a new drug application with the FDA in the second half of 2019, according to the release.

Efficacy and safety of fixed-combination bimatoprost/timolol ophthalmic solution

Background: Poor adherence to treatment is a problem in glaucoma, and patient dissatisfaction with topical glaucoma medication is a barrier to adherence. The objective of this study was to evaluate glaucoma patients’ satisfaction with fixed-combination bimatoprost/timolol ophthalmic solution (BTFC).
Methods: This observational, multicenter study was conducted in China in adults with glaucoma treated with BTFC for 1–3 months. Five hundred patients answered a questionnaire concerning their demographic characteristics, history of glaucoma and topical glaucoma treatment, and use of BTFC. The primary endpoint was patient satisfaction with BTFC assessed on a 10-point scale (1= very dissatisfied, 10= very satisfied).
Results: Patients received BTFC alone (65%) or with other treatments (35%), most commonly a carbonic anhydrase inhibitor. Most patients (87%) used BTFC as a replacement for other medication, usually a β-blocker or prostaglandin analog; 13% received BTFC as add-on treatment. Key reasons for initiating BTFC therapy were poor efficacy of previous treatment (72% of patients) and side effects of previous treatment (32% of patients). Most patients agreed or very much agreed that BTFC provided better control of intraocular pressure (85% of patients), had a simpler administration (87% of patients), and was associated with better tolerance and comfort (82% of patients) compared with their previous treatment. Mean satisfaction scores were significantly higher for BTFC than for previous treatments among all patients (7.8 versus 6.0; P<0.0001) and within patient subgroups based on demographic characteristics, pattern of BTFC use, and previous treatment.
Conclusion: Patients were highly satisfied with BTFC used alone or concomitantly with another topical medication. Patients previously treated with a β-blocker, prostaglandin analog, carbonic anhydrase inhibitor, α-adrenergic agonist, or combination of two medications were more satisfied with BTFC than with their previous treatment. Most reported that intraocular pressure control, tolerability, and ease of administration improved with BTFC.

Keywords: bimatoprost, fixed combination, glaucoma, patient compliance, timolol

Old and New Drug Classes Expanding To Include Glaucoma Treatments

Glaucoma is a heterogeneous disease characterized by the development of increased intraocular pressure (IOP) that leads to structural changes and nerve damage within the eye. Manifestations of this disease include chronic progressive open-angle glaucoma (OAG) and acute angle-closure glaucoma (ACG), both of which may be categorized as either primary or secondary, depending on the underlying cause.Glaucoma ranks among the top five causes of moderate to severe visual impairment and is the third leading cause of blindness worldwide.

Global estimates from 2013 suggest that more than 64 million people aged 40 to 80 years have either primary OAG or primary ACG, and with an increasing elderly population, that number is anticipated to reach 76 million by 2020 and 111.8 million by 2040. As ACG is mainly treated through surgery, this review will focus on chronic therapies used to manage OAG.

Patients with OAG often present with an elevated IOP (normal range: 10–21 mmHg), however, a small subset of patients may develop ocular changes with an IOP < 21 mmHg and are referred to as having normal tension glaucoma. Conversely, some patients with an IOP > 21 mmHg do not go on to develop visual impairment and are referred to as having ocular hypertension (OHT). Control of glaucoma focuses on managing the outflow of the eye’s aqueous humor. The primary exit route is via the trabecular meshwork and through the Schlemm’s canal, also known as conventional outflow, while outflow through the ciliary body and suprachoroidal space, known as unconventional or uveoscleral outflow, accounts for a minor amount of outflow. Topical medications represent the first line of treatment, but if IOP control is inadequate, patients may require escalation to laser-based therapies or surgical procedures.

Several classes of medications are available to treat OAG, but the recommended initial therapy is with a medication from either the beta blocker or prostaglandin analog classes.Prostaglandin analogs work by increasing aqueous humor outflow through the uveoscleral pathway. Beta blockers are believed to act by reducing the production of aqueous humor. A brief overview of the various classes of medications and products available in the United States is provided in Table 1. The usual treatment goal is to achieve a 25%–30% reduction from the patient’s baseline IOP, but other factors such as baseline IOP, pre-existing nerve damage, risk for disease progression, or development of adverse effects may prompt providers to pursue more aggressive or lenient therapeutic goals. Patients may require multiple eye drops from different classes in order to achieve the IOP goal.

Despite the number of effective medications and readily available generic and combination products, there remains a need for new and innovative therapies. One key area for improvement is patient adherence. A survey of patients with glaucoma revealed a number of barriers that prevent effective disease management, including difficulty with effective administration of eye drops, poor medication and disease education, and nonadherence with complex dosing regimens.Some treatments discussed below seek to address adherence through the use of innovative delivery methods that prolong medication activity. Physicians also desire therapies with novel mechanisms that are able to lower IOP more effectively and medications that could provide protection against ocular nerve degeneration.Below (and summarized in Table 2) is a brief overview of several new agents, in no particular order, that have recently been approved or are poised to enter the market in the coming years.

Rhopressa (netarsudil ophthalmic solution)

In December of 2017, the Food and Drug Administration (FDA) approved netarsudil, the first of a new class of medications known as Rho kinase (ROCK) inhibitors. In addition to inhibiting ROCK, this medication also possesses other IOP-lowering mechanisms, such as the inhibition of norepinephrine transport and an ability to reduce episcleral venous pressure. The double-blind, randomized, multicenter trial ROCKET-1 (N=411) compared the efficacy of netarsudil 0.02% dosed once daily at nighttime with timolol maleate 0.5% dosed twice daily. The ROCKET-2 trial (N=756) had a similar design, with an additional netarsudil 0.02% twice-daily dosing arm. Both trials followed patients with OHT or OAG who had an IOP of > 20 mmHg and < 27 mmHg for three months. The primary endpoint in both trials was a reduction in IOP. In ROCKET-1, patients with a baseline IOP < 27 mmHg who received netarsudil demonstrated a 15%–22% reduction in IOP as compared with a 17%–22% reduction in patients who received timolol, but this was not sufficient to demonstrate noninferiority based on prespecified criteria. A post-hoc analysis that focused on patients whose baseline IOP was < 25 mmHg was able to demonstrate noninferiority.

ROCKET-2’s primary efficacy population focused on patients with an IOP < 25 mmHg and was able to demonstrate mean reductions of 3.3–4.6 mmHg and 4.1–5.4 mmHg in patients receiving daily and twice-daily netarsudil, respectively. These reductions were similar to those seen with twice-daily timolol, which produced a 3.7–5.1 mmHg reduction from baseline and demonstrated the noninferiority of netarsudil. In terms of percent reduction in IOP, daily netarsudil was able to achieve a 16%–21% reduction, while twice-daily dosing showed a 22%–24% reduction; twice-daily timolol demonstrated an 18%–23% reduction.

The use of netarsudil appears to be generally well tolerated, with the most common observed adverse effect being conjunctival hyperemia (50%–53%), followed by conjunctival hemorrhage (13%–15%), and cornea verticillata (5%–9%). Other adverse effects including blurred vision, eye pain or erythema, and erythema of the eyelid, were also noted in > 5% of patients.Aerie Pharmaceuticals also conducted the ROCKET-4 trial to demonstrate the six-month safety of netarsudil. Results from this trial, released in April 2017, showed daily netarsudil to be non-inferior to twice-daily timolol. The frequency and severity of effects were seen at similar rates to those in the ROCKET-1 and ROCKET-2 trials.

The entry of netarsudil into the market is exciting as it is a novel, well tolerated, once-daily agent. One limiting factor to this medication is its reduced efficacy in patients with a baseline IOP of 26 mmHg or higher. As Aerie Pharmaceuticals has already obtained approval in the United States, it is anticipated to launch in 2019 in the European Union and in 2021 in Japan.

Roclatan (netarsudil/latanoprost ophthalmic solution)

Roclatan, a combination product containing netarsudil and the prostaglandin analog latanoprost, is also being developed by Aerie Pharmaceuticals. This fixed-dose combination would be administered as a once-daily eye drop in the evening and is formulated as a netarsudil/latanoprost 0.02%/0.005% solution. The IOP-lowering effects of netarsudil are expected to be complemented by increased outflow by way of the uveoscleral pathway, facilitated by latanoprost.

The Mercury 1 trial randomized 718 subjects into three treatment arms: netarsudil monotherapy, latanoprost monotherapy, or netarsudil/latanoprost combination therapy, each dosed once daily. The primary efficacy outcome was mean IOP at three months; patients were observed for 12 months for ocular and systemic safety outcomes. At 90 days, patients who received the combination therapy achieved 1.3–2.5 mmHg lower mean IOP than patients who received latanoprost monotherapy, and 1.8–3.0 mmHg lower mean IOP than patients who received netarsudil monotherapy. Significantly more subjects receiving combination therapy demonstrated a 20% or greater IOP reduction and achieved an IOP of < 18 mmHg. While no serious adverse events were reported, a higher percentage of patients discontinued therapy at three months in the combination (15.5%) and netarsudil monotherapy (17.6%) arms versus latanoprost monotherapy (5.5%), with adverse effects being cited as the most common reason for discontinuation. Conjunctival hyperemia was reported in approximately 50% of patients, with most cases being described as mild. Approximately 5% to 11% of patients reported experiencing conjunctival hemorrhage, pruritus, increased lacrimation, and cornea verticillata.

The Mercury 2 trial evaluated changes in IOP at 90 days in 750 participants receiving netarsudil/latanoprost, netarsudil monotherapy, or latanoprost monotherapy. Similar to the Mercury 1 findings, the combination agent was able to lower IOP an additional 1.5–2.4 mmHg compared with latanoprost monotherapy and an additional 2.2–3.3 mmHg when compared with netarsudil monotherapy. Fifty-six percent of patients receiving netarsudil/latanoprost were able to achieve a diurnal IOP of < 16 mmHg.

An additional clinical trial (Mercury 3) is underway to compare the safety and efficacy of netarsudil/latanoprost with that of the combination bimatoprost/timolol 0.03%/0.5%. This trial, which is still recruiting patients, will aim to enroll 472 participants and evaluate changes in IOP at six months in addition to clinical safety endpoints. Currently, no additional information is available regarding this study, but the anticipated completion date is April 2019. Aerie Pharmaceuticals filed a New Drug Application on May 15, 2018 and expects a decision from the FDA within 10 months.

OTX–TP

Ocular Therapeutix is developing a bio-resorbable canalicular implant that will continuously deliver the prostaglandin analog travoprost for up to 90 days. The active medication is encapsulated in a biodegradable polyethylene-glycol hydrogel that will swell upon implantation to retain its position in the eye. This plug is inserted through noninvasive methods by a specialist and does not require removal as it exits through the nasolacrimal system.This novel delivery system addresses the major issue of poor patient adherence and is poised to be the first of several implantable therapies to enter the major markets.

A phase 2b study evaluated efficacy and safety of a punctum plug of travoprost against timolol maleate 0.5% drops twice daily in 79 patients. Participants were enrolled if they had a diagnosis of OHT or OAG with a mean baseline IOP of ≥ 24 mmHg at Hour 0 and an IOP of ≥ 22 mmHg when checked 4 and 8 hours later. Mean reductions in IOP were evaluated at 30, 60, and 90 days at multiple times each day (8 a.m., 12 p.m., and 4 p.m.). Patients in both groups demonstrated a reduction in IOP from baseline, although those receiving OTX–TP showed a 3.27–3.54 mmHg reduction while those receiving timolol experienced a 5.84–6.29 mmHg reduction. These reductions in IOP were observed at all time points throughout the day. The reported rates of ocular (39.4% vs. 37.5%) and non-ocular (9.1% vs. 7.5%) adverse effects were similar in the OTX–TP and timolol arms, respectively. The most common adverse effects were dacryocanaliculitis (12.1% vs. 10%), acquired dacryostenosis (6.1% vs. 5%), eyelid edema (6.1% vs. 0%) and scar (6.1% vs. 0%) in the OTX–TP and timolol groups, respectively.

Ocular Therapeutix is now enrolling patients for a phase 3, placebo-controlled trial evaluating the efficacy and safety of OTX–TP in the treatment of OAG or OHT. This trial will aim to enroll 550 patients with a primary endpoint of changes in IOP at Weeks 2, 6, and 12, at 8 a.m., 10 a.m., and 4 p.m. Ocular Therapeutix expects to complete this trial in December 2018.While OTX–TP has the advantage of a noninvasive route of administration and is likely to be the first long-acting implant to enter the market, the lower impact on IOP as compared with timolol drops observed in the phase 2b trial and lack of active control in the upcoming phase 3 trial may make some providers unsure of its place in therapy.

Bimatoprost Sustained-Release Ocular Implant

Allergan is reformulating its prostaglandin analog, bimatoprost, into a sustained-release ocular implant as a way to enhance patient adherence. Bimatoprost SR would continuously deliver medication over six months after being inserted via injection into the anterior chamber of the eye through a noninvasive procedure.

A phase 1/2 prospective, dose-ranging trial that examined 75 patients with OAG demonstrated a rapid and sustained lowering of IOP with bimatoprost SR. Following a washout period, enrollees intracamerally received various doses in the study eye while the other eye was treated with topical bimatoprost 0.03%. Overall mean IOP reductions of 7.2, 7.4, 8.1, and 9.5 mmHg were seen in patients receiving 6, 10, 15, and 20 mcg of bimatoprost SR, respectively, as compared with an 8.4 mmHg reduction with topical bimatoprost. Patients initially reported higher rates of adverse effects such as eye pain, foreign body sensation in the eye, and conjunctival hemorrhage with bimatoprost SR but these symptoms subsided within two days of onset. Following Day 2, the eye receiving bimatoprost SR had less reported conjunctival hyperemia (6.7% vs. 17.3%) than the eye receiving topical bimatoprost, while reports of other adverse effects remained similar between the eyes. When questioned at Day 8, 79.7% of patients reported the procedure to be less burdensome than anticipated and, at Week 12, 77% of patients were very or extremely likely to have another implant procedure.

An ongoing phase 3 trial enrolling 594 patients with OAG or OHT is comparing twice-daily timolol drops to two undisclosed doses of bimatoprost SR administered on Day 1, at Week 16, and at Week 32. The primary outcome will be changes in IOP from baseline to Week 12; however, patients will continue to be followed for a 12-month treatment duration plus an additional eight-month extended follow-up.A second trial, similarly designed, is aiming to enroll 600 patients and has an estimated primary completion date of March 2019. Two additional trials are comparing bimatoprost SR with selective laser trabeculoplasty in patients with OAG or OHT who are unable to be controlled with topical IOP-lowering therapies. In these trials, an undisclosed dose of bimatoprost SR will be administered on Day 1, at Week 16, and at Week 32. The primary outcome will be changes in IOP at Week 24. Investigators seek to enroll 160 patients for each study and have estimated primary completion dates of November 2019 and May 2020.

DE-117

Santen Pharmaceutical is developing a novel agent that acts on a new target in the prostaglandin pathway, the prostaglandin EP₂ receptor. While other prostaglandin analogs bind to the F2-alpha receptor, DE-117 activates the EP₂ receptor and is thought to lower IOP by regulating outflow through the conventional pathways. This novel mechanism may position DE-117 to be a viable option in patients for whom other prostaglandin analogs have not adequately lowered IOP. In November 2017, Santen filed for approval of DE-117 in Japan while continuing to conduct trials in other markets. There are several clinical trials involving DE-117 for which enrollment is complete but results have not yet been posted.

Among these trials: The phase 2 SEE-1 trial, evaluating five doses of DE-117 against latanoprost among 184 participants in several centers across the United States, was listed as having completed enrollment as of April 2018; a long-term, open-label trial known as RENGE, involving 125 patients and that compared two groups of DE-117 monotherapy with patients receiving the combination DE-117 and timolol ophthalmic solution, was listed as having been completed in November 2017, and the AYAME study, which also evaluated two doses of DE-117 against a placebo arm as well as a latanoprost arm in 253 patients with OAG and OHT.

One trial for which results are available evaluated four varying concentrations of DE-117 against placebo and latanoprost in 91 patients. At the end of 4 weeks, investigators found that a concentration of 0.002% of DE-117 performed the best and matched the IOP-lowering effect of latanoprost. The most commonly observed adverse effects in the 0.002% dosing arm, all seen in approximately 14% of patients, included conjunctival and ocular hyperemia, photophobia, and eye pain.²⁸ The only trial listed as recruiting patients is a phase 3 trial comparing DE-117 directly to latanoprost in patients with OAG or OHT in an anticipated 360 patients. The primary outcome is mean diurnal IOP at three months, and the expected completion date is November 2018.

CONCLUSION

Several other long-acting formulations of established medications are in the early stages of development, which suggests that addressing the issue of poor patient adherence is an area of keen interest. In addition, new medications belonging to established classes, such as prostaglandin analogs, are in early development, as are new therapeutic classes such as guanylate cyclase activators. With these novel treatment options on the horizon, better management of glaucoma looks promising for the near future.

Author bio:

Dr. Kish is an Associate Professor of Pharmacy Practice at Long Island University, LIU Pharmacy (Arnold and Marie Schwartz College of Pharmacy and Health Sciences), in Brooklyn, New York.

Buy Careprost Online

Careprost is one of the best generic for Latisse (Bimatorprost) under low prices and shipping from India.

Active substance:	Bimatoprost
U.S. Brand:	Latisse
Indian Brand:	Careprost
Mfd by:
Strength:	0.03%
Form release:	3ml bottle
Shipping time:	7 – 21 days
Best price:	12.00 USD
Order:	through request form

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DescriptionHow to take?Common Side EffectsLatest New'sPhoto's

Careprost is made by SunPharma company which is founded in 1983, very trusted company in India, and in the world. Careprost is eyedrops for eyelashes. Active ingredient of Careprost from SunPharma is Bimatoprost with strength 0.03% it’s enoght for eyelashes. Usually this is cosmetic medicine and do not require a prescription, but you should to take Careprost very strictly with instructions. If you search where and how to order generic latisse, or another name: Careprost, we can offer this. We sell careprost many years with best prices and delivery time. We can ship Careprost to United States, United Kingdom, Australia, and many other countries, in wich customs do not strictly, you can contact us with request button, or page on our website: WEMAILMD.COM

Careprost should be applied strictly on the growth line of the TOP eyelashes. Some drop a droplet into the cap, dip the brush in there and already apply directly to the growth line.

The possible side effects is a hyperpigmentation (darkening) of the tissues of the upper eyelid and eyelashes, which persists throughout the period of use of the Careprost. As a rule, after its cancellation, hyperpigmentation disappears completely.

Hypertrichosis (active hair growth) is possible in areas of skin exposed to contact with Careprost solution outside the application areas.

Very rare: eye irritation, conjunctival hyperemia, redness of the eyelids, skin hyperpigmentation, dry eye symptoms.

1 Life-Changing Beauty Hacks That Are Way Cheaper Than Eyelash Extensions

1. A lash serum

Though lash serums seem like they’re all talk, some actually deliver with some seriously great results. Products like Latisse or Careprost can really get your lashes into great, long and dark shape. If you’re coming off extensions, getting used to your natural lashes can be a big adjustment. Serums can help you get that lush natural lash you want without compromising on your lash health. You can grab an affordable one off of Amazon.

How to Grow Your Eyelashes Really, Really Long

How can I stimulate my eyelashes to grow?

If you’ve ever watched TV or opened a magazine, you’ve likely heard of a product called Latisse—the only FDA-approved eyelash growth serum on the market. It was originally created as eye drops for glaucoma (high eye pressure), but doctors noticed its other benefit: the ability to grow longer, thicker eyelashes.

After a few iterations and ingredient refinements, Latisse was born, using the active ingredient bimatoprost to help grow your existing lashes and stimulate the growth of new hairs in four to six weeks. Pretty cool, huh? The only little hurdle is that it’s by prescription only, so you gotta go to a derm or doctor to get it.

Which brings us to your next thought: What about the random eyelash serums I see on articles and Instagram? And, ahem, right this way…

Global Eyelashes Enhancing Agents Market Insights Report 2019-2023: Top Manufacturer Estee Lauder, Allergan, Rodan & Fields, Skin Research Laboratories

The “Eyelashes Enhancing Agents Market” globally is a standout amongst the most emergent and astoundingly approved sectors. This worldwide market has been developing at a higher pace with the development of imaginative frameworks and a developing end-client tendency. The worldwide Eyelashes Enhancing Agents market is an enlarging field for top market players Estee Lauder, Allergan, Rodan & Fields, Skin Research Laboratories, ATHENA COSMETICS, Grande Cosmetics, Beauty Essentials. This report gives an exhaustive appraisal of the Eyelashes Enhancing Agents market driving components, which are perceived reliant on the requests of end-client, variable changes in the market, preventive components, and administrative understanding.

The Eyelashes Enhancing Agents market sections are extensively bifurcated on steady data, for example, improvement, quality, dependability, end-client requests, uses, and The strike of the global Eyelashes Enhancing Agents market is mentioned in the part of those areas, It demonstrates various segments Repairing Damaged Eyelashes, Nourishing and sub-segments Bimatoprost, Lash-Building Serum, Skincare Ingredients of the global Eyelashes Enhancing Agents market. The Eyelashes Enhancing Agents market is the cornerstone of the general improvement conditions and desires, as the development of a specific idea needs different analysis, activities, estimates, and philosophies mechanically. We conveyed a point by point outline of the whole key Eyelashes Enhancing Agents market players who have significant score concerning demand, revenue, and deals through their solid administrations. The global Eyelashes Enhancing Agents market report illustrates the profound outline of existing developments, particulars, parameter, and creation. The Eyelashes Enhancing Agents market likewise conveys a total survey of the money related exciting ride in regards to request rate and satisfaction extents.

The Eyelashes Enhancing Agents market comprises of a huge regional analysis with various mainstream associations, producers, and sellers. The Eyelashes Enhancing Agents statistical surveying report additionally gives an estimate based on the cutting edge business developments and logical procedures. The Eyelashes Enhancing Agents market report comprises every single clever requirement, constraints, and furthermore has in detail illumination of the recorded information related to the broke down present and future energy that may concern the development. The smallest change in the creation profile of Eyelashes Enhancing Agents coordinates to real adjustment in the products model, fabricating strategy, and research and advancement, these general factors that are in connection to generation are well-clarified in the worldwide Eyelashes Enhancing Agents statistical surveying report point-to-point and with flowcharts.

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cosopt

Buy Generic Cosopt

Alternative for Cosopt is Dorzox T from Cipla

Active substance:	Dorzolamide + Timolol
U.S. Brand:	Cosopt
Indian Brand:	Dorzox T
Mfd by:
Strength:	2% + 0.5%
Form release:	5ml bottle
Shipping time:	7 – 21 days
Best price:	9.15 USD
Order:	through request form

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DescriptionHow to take?Common Side EffectsLatest New'sPhoto's

Dorzolamide + Timolol (DORZOX T) is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). The IOP-lowering of COSOPT administered twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol administered twice a day and 2% dorzolamide administered three times a day

Dorzox T (COSOPOT) (dorzolamide hydrochloride-timolol maleate ophthalmic solution) is the combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent. This medication works by decreasing the amount of fluid within the eye. Timolol belongs to a class of drugs known as beta-blockers, and dorzolamide belongs to a class of drugs known as carbonic anhydrase inhibitors. DORZOX T (Dorzolamide + Timolol ) is supplied as a sterile, clear, colorless to nearly colorless, isotonic, buffered, slightly viscous, aqueous solution.

Resources: webmd, rxlist,

The dose is one drop of Dorzolamide + Timolol in the affected eye(s) two times daily. If more than one topical
ophthalmic drug is being used, the drugs should be administered at least five minutes apart.

Storage
Store COSOPT at 20° to 25°C (68° to 77°F). Protect from light.

More common

Blurred vision
burning or stinging of the eye (when medicine is applied)
feeling of something in the eye

Less common

Back, abdominal, or stomach pain
change in vision
coughing, shortness of breath, troubled breathing, tightness in the chest, or wheezing

Rare

Blistering, peeling, or loosening of the skin
blood in the urine
blue lips, fingernails, or skin

Can Glaucoma be Treated With Cosopt Loaded Contact Lenses?

Dr. Ari Weitzner

The University of Florida has announced a study to determine whether drug eluting contact lenses can be used to treat glaucoma.

The contact lens will be loaded with Cosopt (i.e., timolol maleate and dorzolamide hydrochloride), as well as vitamin E ((+) ?-tocopherol) as an additive for achieving extended release of the drugs.

Effectiveness will be measured as a drop in IOP after using the lenses.

Eye Drop Shortage Concerns Glaucoma Patients

A nationwide shortage of a special kind of eye drop to treat glaucoma has hit close to home for one Franklin teenager.

On January 24, the Food and Drug Administration placed Dorzolamide Hydrochloride and Timolol Maleate (Cosopt) Ophthalmic Solution on its FDA Drug Shortage list .

The manufacturer said it may not have it available until June because a certain substance used to make Cosopt has run low.

Jacob Cuomo, 18, was diagnosed with congenital glaucoma at one month old. He has been without the eye drops for about a week after running out of his prescription.

He said he’s starting to feel more pressure around his eyes daily and concerned about the possibility of going blind.

“You can’t stop thinking about it because the medication is what you need. You’re so use to having it, it’s like what you need and when it changes it ruins the whole cycle,” he said.

Jacob takes another eye drop medication, but Cosopt is the one he needs more.

He attends Centennial High School and said juggling Advanced Placement and honor classes, plus managing a computer science club, causes a lot of strain on his eyes. He is also a member of the Junior ROTC program.

“I just make sure that I stay in contact with everybody so they know what’s wrong with me. Communication is key to make sure that everything runs smoothly,” he said. “When you don’t take your eye drops say like for a week like it has been for me, you’ll start to feel your eyes start to get bigger. When you lose your vision that’s when you really start to wonder like okay, things are starting to change now.”

Jacob’s mother, Christine, said she’s called pharmacies around Middle Tennessee to see if they have Cosopt.

“I’m just hoping that we can get the drop for him or some alternative or something for him,” Christine said.

The family said they hope Jacob’s doctor can give them the ‘OK’ to receive an important ingredient used in Cosopt soon.

The FDA lists Cosopt-PF, an alternative, as available.

Glaucoma: 3 Ways to Treat a Sneaky Disease

Glaucoma, a group of eye conditions in which the pressure in one or both of your eyes increases and damages your optic nerve, is a sneaky disease with no symptoms in its early stages.

If it’s left untreated, you can lose your sight. Although there is no cure, if it’s detected and treated early, treatment can usually stop or significantly slow down vision loss. Because glaucoma is progressive, the best treatment for you will depend on what stage of the disease you’re in, but the choices are pretty straightforward: eye drops, laser therapy and surgery.

Eye Drops

Eye drops are typically the most common treatment and the one your doctor will likely start with. There are several different types of eye drops that each help decrease the pressure in your eye in different ways. They also have different side effects, though most people don’t notice these.

1. Prostaglandin analogs: “Prostaglandins are the No. 1 prescribed medication, the gold standard,” says Steven Anderson, MD, an ophthalmologist and glaucoma specialist at Sanford Eye and Optical in Fargo, ND. “The beauty of a prostaglandin analog is that it has fewer systemic side effects, it’s a once-a-day drug that lasts for 24 hours, and it’s very effective.” Prostaglandin analogs such as Xalatan (latanoprost) and Travatan (travoprost) lower eye pressure by increasing the outward flow of the fluid in your eye. Possible side effects include eye irritation, dry eye, blurry or cloudy vision and headache.

2. Beta blockers: Once the gold standard before the advent of prostaglandins, these drops lower eye pressure by reducing the amount of fluid your eye produces, slowing down the flow. Examples include Alphagan (brimonidine) and Timoptic (timolol). Possible side effects include eye irritation, fatigue, double vision, headache and dizziness. Barbara Roman, 65, had to switch from Alphagan and Timoptic because both made her extremely tired and drowsy. She’s now on Azopt (brinzolamide), a carbonic anhydrase inhibitor (see #5), and Xalatan (Prostaglandin, #1), and doesn’t notice any side effects at all.

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3. Alpha adrenergic agonists: Lopidine (apraclonidine) and Propine (dipivefrin) are 2 types. These drops lower eye pressure by reducing the amount of fluid your eye produces and increasing the outward flow of fluid. Potential side effects include eye irritation, swelling or pain, blurry vision, fatigue and dry mouth. These drops often cause an allergic reaction.

4. Miotic or cholinergic agents: These eye drops force your pupil to become smaller and help fluid drainage. Examples include Isopto Carpine (pilocarpine) and Phospholine Iodide (echothiophate). They can cause nearsightedness and blurry or dim vision.

5. Carbonic anhydrase inhibitors: Trusopt (dorzolamide) and Azopt (brinzolamide) are eye drops that reduce your eye’s fluid production, though they aren’t used often. This type can also be given as an oral medication like Diamox (acetazolamide) or Neptazane (methazolamide). “I usually use oral medication as a bridge for getting to surgery or when I’m really limited for medication options,” says Dr. Anderson. “The problem is that they can cause a lot of side effects like rashes, lethargy, loss of appetite, a metallic taste in your mouth, electrolyte imbalances and tingling in your hands and feet.”

6. Combination eye drops: These drops use 2 drug types in one drop to get even better results. Examples include Cosopt (dorzolamide [#5] and timolol [#2]), Xalacom (latanoprost [#1] and timolol [#2]), Simbrinza (brinzolamide [#5] and brimonidine [#2]) and Combigan (brimonidine [#2] and timolol [#2]).

Laser Therapy

Laser therapy is the most commonly used procedure for glaucoma and its effect is equivalent to using a single glaucoma medication, says Dr. Anderson.

“It’s an option for a patient who doesn’t want to do drops or who may have a hard time using them,” he says. “You may do it as a first-line agent, or you may use it as an adjunct [supplemental] agent.”

Laser therapy can also be used for people whose medication is creating significant side effects or who are already on 2 or 3 eye drops and still aren’t achieving lower pressure. While the procedure alone may effectively control your eye pressure, you may need one or more glaucoma medications as well.

Laser procedures are performed on an outpatient basis in your ophthalmologist’s office with numbing drops, a contact lens and specific laser targets. Though the procedure usually results in decreased eye pressure, how long the effects last depends on your age, other medical conditions and the type of glaucoma you have. Additional procedures may be necessary later.

Trabeculoplasty: “The most popular [laser therapy] now is the selective laser trabeculoplasty [SLT], which is a newer version of the old argon laser trabeculoplasty. It treats the area within the eye where the fluid filters out,” says Dr. Anderson. “The SLT laser cleans up any pigment and debris that’s clogging up the filter and stimulates the body’s own immune system to come in there and clean up the filter to get better flow in a more natural way.”

One big difference between the SLT laser and the argon laser is that the latter tends to cause scar tissue, reducing its ability to be repeated, and over time becoming less effective. “The SLT laser is a different frequency and so it doesn’t really scar the filtering mechanism, meaning that you can repeat [the procedure] more effectively,” Dr. Anderson says.

Other types: Other types of laser treatments include laser peripheral iridotomy, cyclophotocoagulation and scatter panretinal photocoagulation. The side effects of laser therapy are minimal. Inflammation and discomfort do occur, but they’re generally mild and easily treated with drops. Eye pressure spikes are a risk, but rare. This did happen to Roman after one of many laser treatments, and she had to have an emergency needle procedure to get the pressure down.

Mary Gordon, 70, was diagnosed with acute angle-closure glaucoma 15 years ago and has had multiple trabeculoplasties, as well as many laser peripheral iridotomies, in which one or more holes are made in your iris with a laser. “The procedures were easy, done at the office, and there was no pain and no recovery time,” she says.

Roman was diagnosed with early-onset open-angle glaucoma when her kids were still young. “It was a shock to get this diagnosis at such a young age and I hadn’t noticed any symptoms,” she says. “Understandably, I now crusade friends and family to get checked.”

Her glaucoma is thought to be one outcome from the chemotherapy, radiation and prednisone she had for stage 4 lymphoma in 1983. She has also had multiple laser treatments “hoping to arrest progression, but unfortunately, glaucoma continues to progress,” she says. “It was surprising to me that laser treatments have been quick, easy and painless.”

Surgery

Glaucoma surgery is usually reserved for patients for whom medications and laser treatments haven’t worked. “When you’re judging a patient with glaucoma, you think, ‘What is the ideal pressure for this patient?’ If they’re above that ideal pressure either on drops or after having laser therapy, then surgery is considered because we’re trying to prevent irreversible vision loss,” says Dr. Anderson. Most of these surgeries will involve a hospital or surgery center and recovery may take a few weeks.

Minimally invasive glaucoma surgery (MIGS): This surgery uses “microscopic metal or synthetic tubes in the eye to provide another pathway for the fluid to get out to lower the pressure,” Dr. Anderson says. It’s being researched and developed as a safer way to treat glaucoma than traditional surgery, while also potentially lessening your need for eye drops. One type of MIGS involves a device called a trabectome, which uses heat to cut away tiny amounts of tissue from the mesh inside of your eye, lowering the buildup of fluid and eye pressure.

Last year, Gordon had a procedure in her left eye called endocyclophotocoagulation (ECP) along with her cataract surgery.

ECP is a type of minimally invasive surgery and uses a laser to cause inflammation and scarring, which in turn decreases your eye pressure. About 2 months after ECP and using dorzolamide HCL and timolol maleate, a combination eye drop, twice a day in both eyes, Gordon’s eye pressure is within normal limits. She recently had ECP in her right eye as well with similar results. After having pressure in the 30s for years, she’s thrilled with the improvement.

Filtering surgery: This may be a trabeculectomy or a trabeculectomy with an EX-PRESS shunt. In a trabeculectomy, small amounts of tissue from the mesh inside of your eye are removed, but it’s more invasive than the trabectome procedure and may have more side effects.

The EX-PRESS shunt is “a stainless steel tube that’s placed in the eye that provides a pathway for the fluid to get out,” says Dr. Anderson. “In my practice, it’s my go-to surgery in many cases. I find it very effective in getting pressures where I want. It gives me a lot of control and good results.” Because trabeculectomy can result in scarring, an anti-scarring medication like mitomycin-C is used to prevent this from happening.

Aqueous shunt surgery: This is typically done with a Baerveldt, Molteno or Ahmed shunt, which are “implants that are designed to provide better outflow and reduce the risk of scarring,” Dr. Anderson says. “The shunts are for more severe glaucoma and for people who’ve failed other surgeries.” Roman is in the process of getting a consult to have an Ahmed shunt placed in her right eye “in an attempt to keep it from deteriorating to the same condition as my left eye,” which is in the severe stage, she says.

The Marijuana Controversy

You may have heard that marijuana helps glaucoma. However, the American Academy of Ophthalmology does not recommend using marijuana as a glaucoma treatment. Marijuana can lower your blood pressure, causing decreased blood flow to your optic nerve, which increases your risk of vision loss. Although marijuana does lower the pressure in your eye, this effect only lasts for a few hours, whereas eye drops last a lot longer.

For the effects to be long-lasting, you would need to use marijuana every few hours, day and night, which is harmful to your body and limits your daily activities, such as driving. “I don’t think you want to live a lifestyle where you’re inhibited by the drug all day,” notes Dr. Anderson. “I don’t prescribe it.”

New and Upcoming Treatments

In 2017, two new eye drops were approved for glaucoma. Vyzulta (latanoprostene bunod) is the first medication for glaucoma to contain nitric oxide, a chemical that may affect blood flow to the optic nerve. It also contains a prostaglandin analog, so the potential side effects are similar to that of prostaglandins. Rhopressa (netarsudil) is in a new class of eye drops called rho-associated protein kinase inhibitors. It improves fluid drainage and decreases fluid production.

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Dorzolamide is sold under various trade names, some of which are Trusopt (us brand) and Dorzox (made by Cipla). Dorzolamide is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (e.g., ocular hypertension). Dorzolamide in India available under brand name Dorzox wich is made by Cipla, trusted company, we offer to buy from us this medication at one of best prices on the market, we offer two ways of shipping to US, UK, AU, just contact us for future information regarding Generic Trusopt eye-drops with cheap prices.

Ophthalmic dorzolamide comes as a solution (liquid) to instill in the eye. Dorzolamide eye drops are usually instilled three times a day.

To instill the eye drops, follow these steps:

Wash your hands thoroughly with soap and water.
Check the dropper tip to make sure that it is not chipped or cracked.
Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
Brace the remaining fingers of that hand against your face.
While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
Place a finger on the tear duct and apply gentle pressure.
Wipe any excess liquid from your face with a tissue.
If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
Wash your hands to remove any medication.

Use this medication regularly in order to get the most benefit from it.

https://medlineplus.gov/druginfo/meds/a697049.html

burning or stinging in your eye;
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a bitter taste in your mouth.

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Drug availability, pricing negatively affect the practice of glaucoma

Better education on price and more competition in the drug marketplace are needed to help bring down the cost of glaucoma medications.

Physicians, insurers, pharmacists, regulators, and patients should all be part of the mix in making glaucoma medications more affordable, said Joshua D. Stein, MD. This can be challenging, and prices for many glaucoma medications continue to increase, said Dr. Stein, University of Michigan, Ann Arbor, MI.

The main reasons for high medication prices in the United States are market exclusivity and limited competition. New agents typically are awarded 7 years of market exclusivity by the FDA.

However, the actual median length of market exclusivity is 12 years for most medications and more than 14 years for first-in-class medications. This is because that time period of exclusivity can extend due to regulatory review, clinical trials, or testing done in children, Dr. Stein said.

“For glaucoma medications, the time of patent exclusivity ranges from 7 to 15 years for common agents,” Dr. Stein said.

Drug shortages also can affect patient use of drugs. Some contributing factors for this include a lack of raw ingredients, which was the reason cited for a limited supply of dorzolamide and dorzolamide-timolol, Dr. Stein explained.

https://www.ophthalmologytimes.com/article/drug-availability-pricing-negatively-affect-practice-glaucoma

Important Medication in Short Supply for Glaucoma Patients

An important medication for glaucoma patients is in short supply. Patients like Ronald Webb rely on a prescription medication called “Dorzolamide” to see. He uses the eye drops twice a day.

“One of my eyes is almost gone,” Webb said. “It doesn’t matter if you hold two fingers up or whatever, I can’t see anything.”

Glaucoma (According to the National Eye Institute)

A group of diseases that damage the eye’s optic nerve and can result in vision loss and blindness.

Who is at risk?

African Americans over age 40
Everyone over age 60, especially Mexican Americans
People with a family history of glaucoma

Symptoms of Glaucoma

At first, open-angle glaucoma has no symptoms. It causes no pain. Vision stays normal. Glaucoma can develop in one or both eyes.
Without treatment, people with glaucoma will slowly lose their peripheral (side) vision.
Over time, central vision (straight-ahead) may decrease over time until no vision remains.

But suddenly Dorzolamide wasn’t available at his pharmacy, or anywhere else he checked. According to the FDA website, the drug has been in shortage since January 24th. Instead, Webb says he’s been prescribed an alternative drug called “Azopt” which is much more expensive.

“It costs $190, compared to the $18 I was paying before,” he said. “A big price difference.”

According to one of the pharmaceutical companies that makes Dorzolamide, the drug is on backorder and unclear when it will be readily available.

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Basicaly, Bimat is recommended to use up to 16 weeks up to good changes in your eyelashes. It has to be applied once a day for 14 weeks and thereafter can be adjusted to 1-3 times a week. Consult your physician before stop using or start the solution.

Make sure your face is clean. Remove your makeup and remove your contact lenses if you wear them. Wash your hands to prevent germs from getting on or near your eyes.
Remove the applicator from the tray that it is packaged in. Hold the applicator horizontally. Gently squeeze the bottle allow one drop of Latisse to come out onto the applicator. Do not put it on the very tip, but the area right before the tip. You will not want to waste any drops, as it is expensive.
Draw the applicator with the Latisse on it along the base of the upper eyelashes starting from the inner part of your eyelash line to the outer part. Do not apply to the lower lid. Do not instill Latisse into the eye. (You don’t need to use much Latisse to make your lashes grow.)
Blot any excess Latisse that may be on the eyelid with a tissue. Try not to allow the Latisse to enter your eyes.

Source

Redness of the thin tissue over the white part of the eye (conjunctiva)
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How to Grow Your Eyelashes Really, Really Long

here is an article from popular website:

How can I stimulate my eyelashes to grow?

If you’ve ever watched TV or opened a magazine, you’ve likely heard of a product called Latisse—the only FDA-approved eyelash growth serum on the market. It was originally created as eye drops for glaucoma (high eye pressure), when doctors noticed its other benefit: the ability to grow longer, thicker eyelashes.

After a few iterations and ingredient refinements, Latisse was born, using the active ingredient bimatoprost to help grow your existing lashes and stimulate the growth of new hairs in four to six weeks. Pretty cool, huh? The only little hurdle is that it’s prescription only, so you gotta go to a derm or doctor to get it.

Which brings us to your next thought: What about the random eyelash serums I see on articles and Instagram? And, ahem, right this way…

Do OTC eyelash growth serums really work?

Not to further complicate a topic that’s already complicated enough, but this question is a loaded one. If your friends have been using OTC lash serums and *swear* they’ve gotten longer, thicker lashes, it’s very possible they’re using a product that contains an ingredient comparable to bimatoprost.

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“There are some non-prescription lash serums that contain similar growth ingredients, like isopropyl cloprostenate, but these aren’t FDA-regulated or approved,” says Dr. Haberman. So just because you can buy them from your mom’s best friend, it doesn’t mean these lash serums are totally harmless to try. As with any medication, there are side effects to take into consideration before painting your whole eye with the stuff.

Are lash serums safe?

Yes, no, and possibly. There’s good reason (well, actually, reasons plural) why you need a prescription to get your hands on Latisse: It’s an actual drug (for glaucoma!), which means an actual doctor needs to make sure it won’t interfere with other medications you’re taking or have a negative side effect on your eyes.

And you know all those rumors about someone’s eye color changing from using an eyelash serum? Yeah, that’s a possibility if you’re using a formula with growth ingredients. According to Dr. Haberman, if the serum gets inside the eye, those with lighter eyes could notice a change in the color of their irises after repeat exposure. In other words, your baby blues could end up brown if you’re not applying the product carefully, thinly, and only to your lash line.

Other risks: A growth serum can also cause discoloration of the skin and/or irritation and puffiness of the lid if it seeps into your eye. Of course, like all side effects, these are a possibility, not a guarantee—some people can use lash serums without any issues, but this is still a good reminder to always read the ingredients list and talk to your doctor, first.

Long Lashes Without Prescription, but With Risks

If women want to grow longer, fuller, darker eyelashes, Brooke Shields suggests on a ubiquitous television advertisement that they ask their doctors if Latisse is right for them.

But in the case of Latisse, which has sold more than a million bottles to date and gained something of a cult following, it turns out to be easy to bypass a doctor’s prescription or visit.

Some salon workers dispense it to clients who go in for facials. Web sites in the United States and abroad sell it outright with few questions asked. Even doctors are getting into the act: for example, Dr. Anshul V. Gambhir, a former primary care doctor, runs www.latisse.bz, which boasts that it is the “largest Latisse retailer.” All it takes to get Latisse mailed out — without ever seeing him — is filling out a medical history, which he reviews, and typing in a valid credit card number.

“We are doing a ton of business,” said Dr. Gambhir, who also offers Latisse at his three offices in Pennsylvania.

Most people use Latisse, a topical solution, with few, if any, complaints. But the drug can cause redness, itchiness and irritation, which go away if use is discontinued. Less common is eyelid discoloration, which Allergan, the manufacturer, says “may be reversible.” A rare side effect that has captured the most attention is the chance that one’s hazel or blue eyes could turn brown — forever.

The Natural Way to Get Longer Lashes (That Actually Works)

Latisse lash serum is a popular solution to help you grow longer eyelashes, but studies have shown that it can cause irritation to the eye for certain people. The FDA warns that in addtion to eye irritation, Latisse can also cause skin discoloration and even potentially change your eye color permanently. Yep.

Unfortunately, other over-the-counter products that promise eyelash growth aren’t much better.

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Overdose may lead to extreme dizziness, fainting, or painful or prolonged erection.

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US FDA issues import ban on Ajanta Pharma’s Kamagra tablets

An import ban is issued when evidence exists for the marketing or promotion of unapproved drugs into the US

Mumbai: The US Food and Drug Administration has issued an import alert on Ajanta Pharma Ltd’s generic male erectile dysfunction tablet Kamagra, which is manufactured at the company’s facility at Paithan in Maharashtra, according to details on the US drug regulator’s website.

The US regulator has issued import alert 66-41 on Kamagra. This import ban is issued when evidence exists for the marketing or promotion of unapproved drugs into the US.

Shares of Ajanta Pharma which plunged 14% on the news recouped some losses later, and were trading 5.22% lower at Rs1,690.55 at 2.00 PM on the BSE, while the benchmark Sensex was up 0.73% at 27315.58 points.

In a filing to stock exchanges, Ajanta Pharma said there is no import alert on the company’s Paithan unit and that it continues to supply to the US market. The company did not specify if there is an import ban on the drug in question. “We do not sell this product in the US,” a company spokesperson told Mint.

Kamagra tablets, which contain sildenafil citrate, were banned by the US drug regulator in 2009 as well.

According to a research analyst, Ajanta Pharma’s drug does not have US FDA approval and so, if it is entering the US, it would be through some unofficial channels. Hence, there will not be any financial impact on the company because of this action by the regulator, said the analyst, who did not wish to be named citing company policy.

Ajanta Pharma manufactures tablets, capsules and dry powder at the Paithan facility. Besides, it has five other manufacturing plants.

Ajanta Pharma is scaling up its business in the US market. As of September-end, 2016, the company had received 15 product approvals, while 12 abbreviated new drug applications (ANDAs) were pending with the US FDA for approval. It plans to file 8-12 ANDAs with the US FDA every year.

The benefits of buying Viagra from a pharmacy, over the counter

In New Zealand, most men in need of assistance for sexual performance can walk into a pharmacy and buy their Viagra over the counter.

Men in Australia can’t do this. They need to visit their GP to obtain a script, with repeats, and when these run out they need a new script.

Like men across the globe, however, they may buy their drugs over the internet. But there are risks.

VIAGRA NOW AVAILABLE OVER THE COUNTER WITHOUT PRESCRIPTION IN UK

Viagra Connect has become available to buy over the counter without a prescription in the UK for the very first time.

In November last year, it was announced that Viagra pills would be sold over the counter in the near future in an effort to stop men illegally purchasing knock-off versions online.

Now, men with impotence will be able to obtain the drug exclusively from Bootspharmacies and online for the next two weeks, before it is then also rolled out across other pharmacies.

The product is geared towards men with erectile problems, which constitutes approximately one fifth of the male British population.

This amounts to 4.3 million men in the UK, according to a 2010 study conducted by Kantar TNS.

Viagra Connect manufacturer Pfizer hopes that this news will encourage men to be more proactive and seek help for erectile dysfunction.

“The launch of Viagra Connect offers men a new and convenient route of access to treat the symptoms of erectile dysfunction,” said Kristie Sourial MRPharmS, medical manager for Pfizer.

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Men arrested for selling 'Viagra mimic' in Phoenix

Two men have been arrested for illegally selling drugs with the same primary ingredient as Viagra.

Phoenix police report that on September 26 they arrested 53-year-old Kevin Reilly and 68-year-old Robert Duane Gregory.

Both men are accused of selling pills made in India containing Sildenafil Citrate, the primary ingredient that is found in Viagra.

Reilly allegedly marketed the medicine as ‘male enhancement/erectile dysfunction pills,’ calling them ‘Blue Diamonds.’

Undercover offices conducted several buys in Tempe and had the pills tested. Authorities with Pfizer, the maker of Viagra, confirmed the pills were a ‘Viagra mimic’ and a counterfeit.

Police say these pills must be purchased with a prescription and were obtained by Reilly in a supply chain that is unregulated by the FDA.

Police say the value of the drugs seized is about $10,000.

Robert Gregory was arrested in Peoria for selling ‘Cenforce200.’ Like ‘Blue Diamonds,’ these pills contain the same primary ingredient and were manufactured in India.

These pills are not authorized for sale in the United States, according to investigators.

Police say Gregory was found with over 2,500 ‘Cenforce200’ pills.

Both men have been charged with the sale of misbranded drugs.

Upstart competitors are threatening Viagra’s market dominance

Viagra is experiencing some performance anxiety.

For 20 years, Pfizer’s “little blue pill” has been synonymous with the cure to erectile dysfunction (ED). But thanks to patent law and a recent court settlement, upstart competitors like Roman and Himsare now able to sell the generic version of Sildenafil, the drug used to treat ED.

Earlier this week, internet users noticed that the hims.com domain name redirected to viagra.com, prompting a theory that Pfizer had nabbed the domain. The theory now appears to be unfounded (hims.com now curiously redirects to menshealth.com), but Pfizer is still right to feel the heat. After 20 years of patent-protection on Sildenafil (ED competitors like Cialis and Levitra use other active ingredients), generic alternatives like Hims have flooded the market in the past year.

As pharmaceutical companies go for the hard sell on erectile dysfunction treatments, many men still lack robust knowledge of sexual health issues.

As an andrologist — a doctor specializing in male diseases — I frequently encounter people who ask me about erectile dysfunction. One recent patient had no quibbles about coming straight to the point. A somewhat bossy man in his 40s or 50s, he strode straight into my consultation room and demanded a prescription for ten boxes of Viagra. When I asked why he needed so much, he replied straight-faced that he was planning a party with a few friends and needed pills to “liven things up a bit.”

Fortunately, most of the time, I’m spared mental images of my middle-aged patients’ more orgiastic maneuvers. Another recent patient was a much more typical case: He ostensibly came to see me about a routine semen analysis, and after the initial consultation — right as he was walking out — he turned back and asked what we in the medical profession call a “doorknob question.” These are often the true reasons for the patients’ visit, and in andrology, it’s often when men confess that all’s not well in the bedroom.

Naturally, I’m not in the business of prescribing industrial amounts of Viagra to just any guy who asks for it. As with everything in medicine, I have to follow certain procedures before putting patients on a course of treatment. In the latter patient’s case, I used an internationally recognized questionnaire to evaluate the extent of the man’s erectile dysfunction and determined that it indeed required treatment. However, just as I was writing him a prescription, the man adopted a serious expression. “Doctor,” he said, “I’ve heard that Viagra has a number of side effects and is even addictive. Would it be possible to give me something else?”

To me, the contrasting attitudes of these two recent patients sum up China’s relationship with medications that treat sexual function — especially frontline medicines like Viagra and Cialis. Some men take them recreationally, even in excess; others regard them with suspicion and don’t dare touch them.

In Chinese, erectile dysfunction is colloquially called yangwei. It’s one of the language’s more visual euphemisms: Yang means “masculine energy,” and wei means “to wilt.” Although attitudes toward sex are becoming more open, it remains taboo to talk about sex in China. Society has historically viewed male sexual dysfunction as shameful, and even though media outlets and internet forums help to promote discussion about the topic, many patients remain ignorant or suspicious of existing medical treatments.

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Pfizer has been maintaining a significant share in the Erectile Dysfunction (ED) market – thanks to its own generic version of the blue pill.

The Erectile Dysfunction (ED) market is not as lucrative as it was used to be; however, that has not bothered much to Pfizer.

The American multinational pharmaceutical corporation headquartered in New York City has been holding a strong share in the ED drug marketplace even though the competition from generic manufactures has been consuming the sales of its blockbuster drug, Viagra.

Viagra contains sildenafil citrate, a drug that was originally intended for use in people with pulmonary arterial hypertension. However, during clinical trials, researchers accidentally found that the drug helped men with stronger and durable erections. After getting the FDA approval, Pfizer introduced Viagra in 1998 and since then, it has been bringing millions and billions of revenue to Pfizer.

However, almost 21 years later, Viagra sales have dropped. Pfizer’s Viagra patent expired in December 2017, opening the floodgates to generic drug-makers.

As generics entered the ED drug market, the sales of the little blue pill in the United States declined dramatically.

In spite of so much generic competition, Pfizer is able to maintain a significant market share, and the credit goes to the launching of its own generic version of Viagra.

In late 2017, the NY-based pharma giant announced it would develop a generic version of Viagra, known as sildenafil, at half the cost of its branded version. Also, the company said it would offer new discount programs as well as increase its copayment card discounts so that the brand version is more accessible to patients.

African Countries Ban Energy Drink Spiked With Viagra

But this one can leave you feeling a little… Stiff.

Power Natural High Energy Drink SX was the go-to energy drink for young men seeking a quick thrill in Zambia. Even the best of us need something to help us rise to the occasion. But this particular energy drink gave a bit more of a rise than some customers bargained for. It’s reported that Natural Power Energy Drink SX is very popular among the young men in Zambia. It’s sold in 500ml plastic cans in grocery stores and bars.

The Zambian government issued a ban on the drink after tests showed it had been spiked with Sildenafil Citrate. Sildenafil Citrate is the brand name for Viagra.

The drink is also exported to African countries such as Uganda, Malawi, and Zimbabwe, according to the manufacturer. In December, the same month Zambia tested the energy drink, The Uganda National Drug Authority said it made similar findings, The tested the drink after a customer complained of constant sweating and a six-hour erection. Not the kind of energy he was seeking. Probably.

Early to rise, early to… the hospital, if your erection lasts longer than 4 hours.

In January, Malawi likewise banned the drink after tests were conducted at the quality control laboratory after the concerns were raised in both Zambia and Uganda.

Pesky government agencies, ruining the best-kept secret in Africa. Where will those young gentlemen get their energy from now??? Just because one guy got a little sweaty and baseball stats weren’t doing the trick… Doesn’t mean it has to ruin everyone else’s good time. And “Natural Power Energy Drink SX”! What a name! I wonder what the SX stands for… Maybe they can rebrand as “Pharmaceutically Enhanced Power Energy Sex Drink”. Doesn’t have the same ring, does it? They’re gonna need bigger cans for that logo.

Viagra 20 Years Later: Here's Why Young, Healthy Men Use The Blue Pill

wo decades after Viagra or Sildenafil Citrate was first released in the market, the blue pill has evolved into something more than just treatment for erectile dysfunction.

In its earlier days, “the miracle drug” was mainly patronized by older men who struggled with what was then known as “impotence.” Now, its market has massively grown as millennials surprisingly enter the fold.

Why are these younger men still dependent on the medication despite being in the pink of health? This very question has puzzled researchers at the VA Boston Healthcare System and to determine the ultimate answer, they conducted an online survey in 2012 involving more than 1,200 sexually active men.

The results were both sad and shocking. Viagra and other oral erectile dysfunction medication are currently taken by recreational users to aide in a psychogenic condition resulting from misuse of the same drugs.

These type of users reported having the similar level of erectile function as those who have never taken the drug. However, they likewise claimed to have low sexual confidence and stronger feelings of dissatisfaction during intercourse.

Researchers determined that both are caused by frequent EDM misuse, which has been proven by the study to adversely affect an individual’s erectile function.

Though further investigation is required, they warn in a paper published July 9, 2012, in the U.S. National Library of Medicine that recreational use of drugs such as Viagra by young and healthy men can potentially impede their “pharmacologically unaided erectile ability.”

The Evolution Of Viagra Pills Over The Past 20 Years

By December 2017, the blue pill has made at least $17 billion in the United States alone. Aside from a large population of recreational users who spend regularly on EDMs, part of this amount was generated through the Pfizer’s marketing efforts.

The company pulled almost every trick out of the bag, from launching studies that linked erectile dysfunction to diabetes and heart failure, to having Senator Bob Dole introduce Viagra to cancer survivors.

Although the media often joked about the drug, medical experts commended it for being the first non-invasive treatment for erectile dysfunction and for setting the stage for men to open up about their reproductive health issues.

“Viagra marks the start of the marketing of sexual dysfunction as a social and individual problem, and one to be solved by medicine,” says Meika Loe, assistant professor of Sociology at Colgate University in New York and author of The Rise of Viagra: How The Little Blue Pill Changed Sex In America.

Nonetheless, she pointed out that its effectiveness remains uncertain as it doesn’t really treat relationships or social ideas affecting a person’s sexual confidence.

At present, Viagra is being sold at its most affordable price since 1998. According to a recent report, prices for branded EDMs are at $70 per pill, while prices for generic versions vary from $35 to $40 if purchased without discounts. Alternatives are also available in the market, such as Cialis and Levitra.

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