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Zopiclone is a type of sleeping pill that can be taken for short-term treatment of severe insomnia.
It helps you fall asleep more quickly, and also helps stop you waking up during the night. It works by affecting a calming chemical in your brain called gamma-aminobutyric acid (GABA).
Zopiclone comes as tablets. It also comes as a liquid for people who find it hard to swallow tablets, but your doctor will have to order this specially.
Zopiclone is indicated for the short-term treatment of insomnia in adults1. The approved adult dose is 7.5 mg taken shortly before bedtime for up to a maximum of 4 weeks. Medsafe has not assessed the safety and efficacy of longer-term use. Use of zopiclone for longer than 4 weeks should be considered ‘off-label’.
If zopiclone is needed to manage insomnia, it should be used in conjunction with non-pharmacological approaches, such as managing expectations about sleep duration, improving sleep hygiene, modifying lifestyle factors, and addressing underlying health issues and psychological stress.
Long term use of zopiclone may cause tolerance and dependence, leading to withdrawal and rebound insomnia if the medicine is stopped abruptly. A gradual reduction in dose and/or frequency of use can reduce the likelihood of withdrawal effects after long-term use.
Zopiclone is eliminated via hepatic metabolism, therefore, hepatic impairment increases the risk of adverse effects. In healthy adults, the elimination half-life of zopiclone after a single dose is 5 hours. In patients with hepatic failure, the elimination half-life is prolonged to nearly 12 hours.
Zopiclone tablets come in 2 different strengths: 3.75mg and 7.5mg.
The usual dose is one 7.5mg tablet, taken just before you go to bed. It takes around 1 hour to work.
A lower dose of 3.75mg may be recommended to begin with if you’re over 65 years old or have kidney or liver problems. Taking a lower dose in these cases reduces the risk of excessive sleepiness and other side effects.
These common side effects of zopiclone happen in more than 1 in 100 people. There are things you can do to help cope with them:
A bitter or metallic taste in your mouth or a dry mouth
Feeling sleepy or tired the next day
Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.
Serious side effects
It happens rarely, but some people have serious side effects when taking zopiclone.
Call your doctor or contact 111 as soon as possible if you:
- get a poor memory (amnesia)
- see or hear things that are not real (hallucinations)
- fall over, especially if you’re over 65 years of age
- think things that are not true (delusions)
- feel low or sad (have depression)
Serious allergic reaction
In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to zopiclone.