TAMSULOSIN — 0.4 mg modified‑release capsules
📦 Product Snapshot
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🧠 Overview
Tamsulosin is a selective alpha‑1A and alpha‑1D adrenoceptor antagonist. It relaxes smooth muscle in the prostate, bladder neck, and urethra by blocking adrenergic receptors, thereby improving urinary flow and reducing symptoms of BPH such as hesitancy, weak stream, and nocturia. It has minimal effect on blood pressure compared to non‑selective alpha‑blockers.
Unlike older alpha‑blockers (prazosin, terazosin), tamsulosin is highly uroselective and does not require dose titration for hypertension. It is often prescribed as first‑line therapy for moderate‑to‑severe lower urinary tract symptoms (LUTS) associated with BPH. Modified‑release formulation allows once‑daily dosing, usually 30 minutes after the same meal each day.
Important combination products exist: tamsulosin is co‑formulated with dutasteride (5‑alpha reductase inhibitor) for dual approach to BPH progression, and with solifenacin (antimuscarinic) for storage and voiding symptoms. These fixed‑dose combinations carry their own brand names and indications.
🏷️ Strengths & Brand Examples
- 0.4 mg modified‑release capsule (standard)
- 0.8 mg (rare, used in specific cases under specialist supervision)
- Contiflo® 0.4 mg (Ranbaxy / Sun Pharma)
- Urimax® 0.4 mg (Cipla)
- Flotral® 0.4 mg (Abbott)
- Tamsulix® D (with dutasteride 0.5 mg)
- Urimax D® / Contiflo D® (tamsulosin 0.4 mg + dutasteride 0.5 mg)
- Vesomni® / Urimax F® (tamsulosin 0.4 mg + solifenacin 6 mg)
⚠️ Safety, Side Effects & Monitoring
- Dizziness, first‑dose orthostatic hypotension
- Retrograde ejaculation (dry orgasm) — most common sexual side effect
- Rhinitis, headache, asthenia
- Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery
- Palpitations, constipation (less frequent)
• IFIS: inform ophthalmologist before cataract surgery; no proven benefit to stopping tamsulosin pre‑op.
• Contraindicated in patients with a history of orthostatic hypotension or severe hepatic impairment.
• Should not be used in combination with other alpha‑blockers.
• Rarely, priapism requires immediate medical attention.
• Caution when driving or operating machinery until response is known.
❓ FAQ
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